4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus

Genome-wide association studies (GWAS) have identified >100 independent susceptibility loci for prostate cancer, including the hot spot at 8q24. However, how genetic variants at this locus confer disease risk hasn’t been fully characterized. Using circularized chromosome conformation capture (4C)...

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Detalles Bibliográficos
Autores principales: Cai, Mingyang, Kim, Sewoon, Wang, Kai, Farnham, Peggy J., Coetzee, Gerhard A., Lu, Wange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776156/
https://www.ncbi.nlm.nih.gov/pubmed/26934861
http://dx.doi.org/10.1038/srep22462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776156/
https://www.ncbi.nlm.nih.gov/pubmed/26934861
http://dx.doi.org/10.1038/srep22462

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