Interaction between hexon and L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors

The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alt...

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Detalles Bibliográficos
Autores principales: Yan, Jingyi, Dong, Jianing, Wu, Jiaxin, Zhu, Rui, Wang, Zhen, Wang, Baoming, Wang, Lizheng, Wang, Zixuan, Zhang, Haihong, Wu, Hui, Yu, Bin, Kong, Wei, Yu, Xianghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776158/
https://www.ncbi.nlm.nih.gov/pubmed/26934960
http://dx.doi.org/10.1038/srep22464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776158/
https://www.ncbi.nlm.nih.gov/pubmed/26934960
http://dx.doi.org/10.1038/srep22464

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