SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load

Restriction of HIV-1 in myeloid-lineage cells is attributed in part to the nucleotidase activity of the SAM-domain and HD-domain containing protein (SAMHD1), which depletes free nucleotides, blocking reverse transcription. In the same cells, the Vpx protein of HIV-2 and most SIVs counteracts SAMHD1....

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Detalles Bibliográficos
Autores principales: Buchanan, Erin L., Espinoza, Diego A., McAlexander, Melissa A., Myers, Stephanie L., Moyer, Adam, Witwer, Kenneth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776177/
https://www.ncbi.nlm.nih.gov/pubmed/26936683
http://dx.doi.org/10.1038/srep22629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776177/
https://www.ncbi.nlm.nih.gov/pubmed/26936683
http://dx.doi.org/10.1038/srep22629

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