Relative bioavailability, food effect, and safety of the single-dose pharmacokinetics of omecamtiv mecarbil following administration of different modified-release formulations in healthy subjects

Objective: Omecamtiv mecarbil is a novel small molecule that directly activates cardiac myosin and increases cardiac contractility without increasing cardiac myocyte intracellular calcium. This study evaluated the relative bioavailability, food effect, and safety of several modified-release (MR) for...

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Detalles Bibliográficos
Autores principales: Palaparthy, Rameshraja, Banfield, Christopher, Alvarez, Paco, Yan, Lucy, Smith, Brian, Johnson, Jessica, Monsalvo, Maria Laura, Malik, Fady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dustri-Verlag Dr. Karl Feistle 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776255/
https://www.ncbi.nlm.nih.gov/pubmed/26709596
http://dx.doi.org/10.5414/CP202458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776255/
https://www.ncbi.nlm.nih.gov/pubmed/26709596
http://dx.doi.org/10.5414/CP202458

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