Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis

Toll-like receptor 9 (TLR9) senses bacterial DNA characteristic of unmethylated CpG motifs to induce innate immune response. TLR9 is de novo expressed in podocytes of some patients with glomerular diseases, but its role in podocyte injury remains undetermined. Since TLR9 activates p38 MAPK and NFkB...

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Detalles Bibliográficos
Autores principales: Bao, Wenduona, Xia, Hong, Liang, Yaojun, Ye, Yuting, Lu, Yuqiu, Xu, Xiaodong, Duan, Aiping, He, Jing, Chen, Zhaohong, Wu, Yan, Wang, Xia, Zheng, Chunxia, Liu, Zhihong, Shi, Shaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776276/
https://www.ncbi.nlm.nih.gov/pubmed/26934958
http://dx.doi.org/10.1038/srep22579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776276/
https://www.ncbi.nlm.nih.gov/pubmed/26934958
http://dx.doi.org/10.1038/srep22579

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