Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

BACKGROUND: The polycomb complex protein BMI-1 (BMI-1) is a putative oncogene reported to be overexpressed in multiple myeloma (MM). Silencing of BMI-1 was shown to impair the growth and survival of MM cells. However, therapeutic agents specifically targeting BMI-1 were not available so far. Here, w...

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Detalles Bibliográficos
Autores principales: Bolomsky, Arnold, Schlangen, Karin, Schreiner, Wolfgang, Zojer, Niklas, Ludwig, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776359/
https://www.ncbi.nlm.nih.gov/pubmed/26935956
http://dx.doi.org/10.1186/s13045-016-0247-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776359/
https://www.ncbi.nlm.nih.gov/pubmed/26935956
http://dx.doi.org/10.1186/s13045-016-0247-4

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