The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

BACKGROUND: Alzheimer’s disease (AD) is characterized by extracellular β-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and microglia-dominated neuroinflammation. The Nogo/NgR signal pathway is involved in AD pathological features, but the detailed mechanism needs further investigation. Our p...

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Detalles Bibliográficos
Autores principales: Fang, Yinquan, Yao, Lemeng, Li, Chenhui, Wang, Jing, Wang, Jianing, Chen, Shujian, Zhou, Xin-fu, Liao, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776389/
https://www.ncbi.nlm.nih.gov/pubmed/26939570
http://dx.doi.org/10.1186/s12974-016-0522-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776389/
https://www.ncbi.nlm.nih.gov/pubmed/26939570
http://dx.doi.org/10.1186/s12974-016-0522-x

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