Tumour Cell Heterogeneity

The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and main...

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Detalles Bibliográficos
Autores principales: Gay, Laura, Baker, Ann-Marie, Graham, Trevor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776671/
https://www.ncbi.nlm.nih.gov/pubmed/26973786
http://dx.doi.org/10.12688/f1000research.7210.1
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author Gay, Laura
Baker, Ann-Marie
Graham, Trevor A.
author_facet Gay, Laura
Baker, Ann-Marie
Graham, Trevor A.
author_sort Gay, Laura
collection PubMed
description The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.
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spelling pubmed-47766712016-03-10 Tumour Cell Heterogeneity Gay, Laura Baker, Ann-Marie Graham, Trevor A. F1000Res Review The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment. F1000Research 2016-02-29 /pmc/articles/PMC4776671/ /pubmed/26973786 http://dx.doi.org/10.12688/f1000research.7210.1 Text en Copyright: © 2016 Gay L et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gay, Laura
Baker, Ann-Marie
Graham, Trevor A.
Tumour Cell Heterogeneity
title Tumour Cell Heterogeneity
title_full Tumour Cell Heterogeneity
title_fullStr Tumour Cell Heterogeneity
title_full_unstemmed Tumour Cell Heterogeneity
title_short Tumour Cell Heterogeneity
title_sort tumour cell heterogeneity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776671/
https://www.ncbi.nlm.nih.gov/pubmed/26973786
http://dx.doi.org/10.12688/f1000research.7210.1
work_keys_str_mv AT gaylaura tumourcellheterogeneity
AT bakerannmarie tumourcellheterogeneity
AT grahamtrevora tumourcellheterogeneity

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