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Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action
The polymers from mastic gum of Pistacia lentiscose and subspecies of Pistacia atlantica, (sp. kurdica, mutica and cabolica) have been isolated and characterised by gel permeation chromatography (GPC) and (13)C NMR spectroscopy as cis-1,4-poly-β-myrcenes. They were screened against Helicobacter pylo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Canadian Center of Science and Education
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777025/ https://www.ncbi.nlm.nih.gov/pubmed/22980106 http://dx.doi.org/10.5539/gjhs.v4n1p149 |
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author | Sharifi, Mohammad Sharif Ebrahimi, Diako Hibbert, David Brynn Hook, James Hazell, Stuart Loyd |
author_facet | Sharifi, Mohammad Sharif Ebrahimi, Diako Hibbert, David Brynn Hook, James Hazell, Stuart Loyd |
author_sort | Sharifi, Mohammad Sharif |
collection | PubMed |
description | The polymers from mastic gum of Pistacia lentiscose and subspecies of Pistacia atlantica, (sp. kurdica, mutica and cabolica) have been isolated and characterised by gel permeation chromatography (GPC) and (13)C NMR spectroscopy as cis-1,4-poly-β-myrcenes. They were screened against Helicobacter pylori and other Gram-negative and Gram-positive bacteria to evaluate their antimicrobial action. In order to further test their hypothesised mode of action, two polymer types were synthesized: one from myrcene, and four from polyvinyl alcohols of different molecular weights, derivatised with p-hydroxybenzoate. The anti-microbial activity of these polymers, evaluated through their ‘kill’ kinetics, was found to be related to their functional groups, their molecular weight and their solubility. |
format | Online Article Text |
id | pubmed-4777025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Canadian Center of Science and Education |
record_format | MEDLINE/PubMed |
spelling | pubmed-47770252016-04-21 Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action Sharifi, Mohammad Sharif Ebrahimi, Diako Hibbert, David Brynn Hook, James Hazell, Stuart Loyd Glob J Health Sci Articles The polymers from mastic gum of Pistacia lentiscose and subspecies of Pistacia atlantica, (sp. kurdica, mutica and cabolica) have been isolated and characterised by gel permeation chromatography (GPC) and (13)C NMR spectroscopy as cis-1,4-poly-β-myrcenes. They were screened against Helicobacter pylori and other Gram-negative and Gram-positive bacteria to evaluate their antimicrobial action. In order to further test their hypothesised mode of action, two polymer types were synthesized: one from myrcene, and four from polyvinyl alcohols of different molecular weights, derivatised with p-hydroxybenzoate. The anti-microbial activity of these polymers, evaluated through their ‘kill’ kinetics, was found to be related to their functional groups, their molecular weight and their solubility. Canadian Center of Science and Education 2012-01 2012-01-01 /pmc/articles/PMC4777025/ /pubmed/22980106 http://dx.doi.org/10.5539/gjhs.v4n1p149 Text en Copyright: © Canadian Center of Science and Education http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Articles Sharifi, Mohammad Sharif Ebrahimi, Diako Hibbert, David Brynn Hook, James Hazell, Stuart Loyd Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title | Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title_full | Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title_fullStr | Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title_full_unstemmed | Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title_short | Bio-Activity of Natural Polymers from the Genus Pistacia: A Validated Model for Their Antimicrobial Action |
title_sort | bio-activity of natural polymers from the genus pistacia: a validated model for their antimicrobial action |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777025/ https://www.ncbi.nlm.nih.gov/pubmed/22980106 http://dx.doi.org/10.5539/gjhs.v4n1p149 |
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