Chronic P‐glycoprotein inhibition increases the brain concentration of escitalopram: potential implications for treating depression

Recent preclinical studies have revealed a functionally important role for the drug efflux pump P‐glycoprotein (P‐gp) at the blood–brain barrier in limiting brain levels and thus antidepressant‐like activity of certain antidepressant drugs. Specifically, acute administration of P‐gp inhibitors, such...

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Detalles Bibliográficos
Autores principales: O'Brien, Fionn E., Moloney, Gerard M., Scott, Karen A., O'Connor, Richard M., Clarke, Gerard, Dinan, Timothy G., Griffin, Brendan T., Cryan, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777256/
https://www.ncbi.nlm.nih.gov/pubmed/27022464
http://dx.doi.org/10.1002/prp2.190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777256/
https://www.ncbi.nlm.nih.gov/pubmed/27022464
http://dx.doi.org/10.1002/prp2.190

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