ADME studies of [5‐(3)H]‐2′‐O‐methyluridine nucleoside in mice: a building block in siRNA therapeutics

The chemical modification 2′‐O‐methyl of nucleosides is often used to increase siRNA stability towards nuclease activities. However, the metabolic fate of modified nucleosides remains unclear. Therefore, the aim of this study was to determine the mass balance, pharmacokinetic, and absorption, distri...

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Detalles Bibliográficos
Autores principales: Lozac'h, Frederic, Christensen, Jesper, Faller, Thomas, van de Kerkhof, Esther, Krauser, Joel, Garnier, Maxime, Litherland, Karine, Catoire, Alexandre, Natt, Francois, Hunziker, Jurg, Swart, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777266/
https://www.ncbi.nlm.nih.gov/pubmed/26977299
http://dx.doi.org/10.1002/prp2.209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777266/
https://www.ncbi.nlm.nih.gov/pubmed/26977299
http://dx.doi.org/10.1002/prp2.209

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