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ADME studies of [5‐(3)H]‐2′‐O‐methyluridine nucleoside in mice: a building block in siRNA therapeutics
The chemical modification 2′‐O‐methyl of nucleosides is often used to increase siRNA stability towards nuclease activities. However, the metabolic fate of modified nucleosides remains unclear. Therefore, the aim of this study was to determine the mass balance, pharmacokinetic, and absorption, distri...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777266/ https://www.ncbi.nlm.nih.gov/pubmed/26977299 http://dx.doi.org/10.1002/prp2.209 |