In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis

The murine Cebpa gene contains a +37 kb, evolutionarily conserved 440 bp enhancer that directs high-level expression to myeloid progenitors in transgenic mice. The enhancer is bound and activated by Runx1, Scl, GATA2, C/EBPα, c-Myb, Pu.1, and additional Ets factors in myeloid cells. CRISPR/Cas9-medi...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Hong, Cooper, Stacy, Friedman, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777376/
https://www.ncbi.nlm.nih.gov/pubmed/26937964
http://dx.doi.org/10.1371/journal.pone.0150809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777376/
https://www.ncbi.nlm.nih.gov/pubmed/26937964
http://dx.doi.org/10.1371/journal.pone.0150809

Ejemplares similares