Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice

Macrophage-mediated inflammation has been implicated in various kidney diseases. We previously reported that Rac1, a Rho family small GTP-binding protein, was overactivated in several chronic kidney disease models, and that Rac1 inhibitors ameliorated renal injury, in part via inhibition of inflamma...

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Detalles Bibliográficos
Autores principales: Nagase, Miki, Kurihara, Hidetake, Aiba, Atsu, Young, Morag J., Sakai, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777421/
https://www.ncbi.nlm.nih.gov/pubmed/26939003
http://dx.doi.org/10.1371/journal.pone.0150886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777421/
https://www.ncbi.nlm.nih.gov/pubmed/26939003
http://dx.doi.org/10.1371/journal.pone.0150886

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