An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors

Nucleoside-based cofactors are presumed to have preceded proteins. The Rossmann fold is one of the most ancient and functionally diverse protein folds, and most Rossmann enzymes utilize nucleoside-based cofactors. We analyzed an omnipresent Rossmann ribose-binding interaction: a carboxylate side cha...

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Detalles Bibliográficos
Autores principales: Laurino, Paola, Tóth-Petróczy, Ágnes, Meana-Pañeda, Rubén, Lin, Wei, Truhlar, Donald G., Tawfik, Dan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777477/
https://www.ncbi.nlm.nih.gov/pubmed/26938925
http://dx.doi.org/10.1371/journal.pbio.1002396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777477/
https://www.ncbi.nlm.nih.gov/pubmed/26938925
http://dx.doi.org/10.1371/journal.pbio.1002396

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