Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling

Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through RNAi, resolve the intestinal tumors formed due to...

Descripción completa

Detalles Bibliográficos
Autores principales: Seth, Chandan, Ruiz i Altaba, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777488/
https://www.ncbi.nlm.nih.gov/pubmed/26939070
http://dx.doi.org/10.1371/journal.pone.0150697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777488/
https://www.ncbi.nlm.nih.gov/pubmed/26939070
http://dx.doi.org/10.1371/journal.pone.0150697

Ejemplares similares