Oxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db Mice

Oxamate (OXA) is a pyruvate analogue that directly inhibits the lactate dehydrogenase (LDH)-catalyzed conversion process of pyruvate into lactate. Earlier and recent studies have shown elevated blood lactate levels among insulin-resistant and type 2 diabetes subjects and that blood lactate levels in...

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Detalles Bibliográficos
Autores principales: Ye, Weiran, Zheng, Yijia, Zhang, Shanshan, Yan, Li, Cheng, Hua, Wu, Muchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777529/
https://www.ncbi.nlm.nih.gov/pubmed/26938239
http://dx.doi.org/10.1371/journal.pone.0150303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777529/
https://www.ncbi.nlm.nih.gov/pubmed/26938239
http://dx.doi.org/10.1371/journal.pone.0150303

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