Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells

Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Here we show that at a physiological concentration (1 μM), DHEAS induces the phosphorylation of the kinase Erk1/2 and of the transcription factors CREB and ATF-1 in the m...

Descripción completa

Detalles Bibliográficos
Autores principales: Papadopoulos, Dimitrios, Dietze, Raimund, Shihan, Mazen, Kirch, Ulrike, Scheiner-Bobis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777551/
https://www.ncbi.nlm.nih.gov/pubmed/26938869
http://dx.doi.org/10.1371/journal.pone.0150143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777551/
https://www.ncbi.nlm.nih.gov/pubmed/26938869
http://dx.doi.org/10.1371/journal.pone.0150143

Ejemplares similares