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Roquin – a multifunctional regulator of immune homeostasis
Roquin-1 (Rc3h1) is an E3 ubiquitin ligase originally discovered in a mutational screen for genetic factors contributory to systemic lupus erythematosus-like symptoms in mice. A single base pair mutation in the Rc3h1 gene resulted in the manifestation of autoantibody production and sustained immunol...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777649/ https://www.ncbi.nlm.nih.gov/pubmed/26673963 http://dx.doi.org/10.1038/gene.2015.58 |