Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

Dysfunction and accumulation of the microtubule-associated human Tau (hTau) protein into intraneuronal aggregates is observed in many neurodegenerative disorders including Alzheimer’s disease (AD). Reversible lysine acetylation has recently emerged as a post-translational modification that may play...

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Detalles Bibliográficos
Autores principales: Gorsky, Marianna Karina, Burnouf, Sylvie, Dols, Jacqueline, Mandelkow, Eckhard, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778021/
https://www.ncbi.nlm.nih.gov/pubmed/26940749
http://dx.doi.org/10.1038/srep22685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778021/
https://www.ncbi.nlm.nih.gov/pubmed/26940749
http://dx.doi.org/10.1038/srep22685

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