Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit. Shisa6 is enriched at hippocampal postsynaptic m...

Descripción completa

Detalles Bibliográficos
Autores principales: Klaassen, Remco V., Stroeder, Jasper, Coussen, Françoise, Hafner, Anne-Sophie, Petersen, Jennifer D., Renancio, Cedric, Schmitz, Leanne J. M., Normand, Elisabeth, Lodder, Johannes C., Rotaru, Diana C., Rao-Ruiz, Priyanka, Spijker, Sabine, Mansvelder, Huibert D., Choquet, Daniel, Smit, August B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778035/
https://www.ncbi.nlm.nih.gov/pubmed/26931375
http://dx.doi.org/10.1038/ncomms10682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778035/
https://www.ncbi.nlm.nih.gov/pubmed/26931375
http://dx.doi.org/10.1038/ncomms10682

Ejemplares similares