Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma

Uveal melanoma (UM) is the most common intraocular malignancy in adults. Despite improvements in surgical, radiation and chemotherapy treatments, the overall survival of UM and prognosis remain poor. In the present study, we hypothesized that Sirtuin 1 and 2 (SIRT1/2), class III histone deacetylases...

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Detalles Bibliográficos
Autores principales: Dai, Wei, Zhou, Jingfeng, Jin, Bei, Pan, Jingxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778058/
https://www.ncbi.nlm.nih.gov/pubmed/26940009
http://dx.doi.org/10.1038/srep22622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778058/
https://www.ncbi.nlm.nih.gov/pubmed/26940009
http://dx.doi.org/10.1038/srep22622

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