Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism

Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface only recently with the discovery of the 5-methylcytosine (5mC)-directed hyd...

Descripción completa

Detalles Bibliográficos
Autores principales: Weber, Alain R., Krawczyk, Claudia, Robertson, Adam B., Kuśnierczyk, Anna, Vågbø, Cathrine B., Schuermann, David, Klungland, Arne, Schär, Primo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778062/
https://www.ncbi.nlm.nih.gov/pubmed/26932196
http://dx.doi.org/10.1038/ncomms10806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778062/
https://www.ncbi.nlm.nih.gov/pubmed/26932196
http://dx.doi.org/10.1038/ncomms10806

Ejemplares similares