mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal inactivation of the Tsc genes causes cysts. Here we identify a new interplay between th...

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Detalles Bibliográficos
Autores principales: Pema, Monika, Drusian, Luca, Chiaravalli, Marco, Castelli, Maddalena, Yao, Qin, Ricciardi, Sara, Somlo, Stefan, Qian, Feng, Biffo, Stefano, Boletta, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778067/
https://www.ncbi.nlm.nih.gov/pubmed/26931735
http://dx.doi.org/10.1038/ncomms10786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778067/
https://www.ncbi.nlm.nih.gov/pubmed/26931735
http://dx.doi.org/10.1038/ncomms10786

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