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The orientation of transcription factor binding site motifs in gene promoter regions: does it matter?

BACKGROUND: Gene expression is to large degree regulated by the specific binding of protein transcription factors to cis-regulatory transcription factor binding sites in gene promoter regions. Despite the identification of hundreds of binding site sequence motifs, the question as to whether motif or...

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Detalles Bibliográficos
Autores principales: Lis, Monika, Walther, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778318/
https://www.ncbi.nlm.nih.gov/pubmed/26939991
http://dx.doi.org/10.1186/s12864-016-2549-x