SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma

Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX...

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Detalles Bibliográficos
Autores principales: Narurkar, Roshni, Alkayem, Mohammad, Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778333/
https://www.ncbi.nlm.nih.gov/pubmed/26949534
http://dx.doi.org/10.1186/s40364-016-0060-9
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author Narurkar, Roshni
Alkayem, Mohammad
Liu, Delong
author_facet Narurkar, Roshni
Alkayem, Mohammad
Liu, Delong
author_sort Narurkar, Roshni
collection PubMed
description Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.
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spelling pubmed-47783332016-03-05 SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma Narurkar, Roshni Alkayem, Mohammad Liu, Delong Biomark Res Review Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis. BioMed Central 2016-03-03 /pmc/articles/PMC4778333/ /pubmed/26949534 http://dx.doi.org/10.1186/s40364-016-0060-9 Text en © Narurkar et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Narurkar, Roshni
Alkayem, Mohammad
Liu, Delong
SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title_full SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title_fullStr SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title_full_unstemmed SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title_short SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma
title_sort sox11 is a biomarker for cyclin d1-negative mantle cell lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778333/
https://www.ncbi.nlm.nih.gov/pubmed/26949534
http://dx.doi.org/10.1186/s40364-016-0060-9
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