A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β

BACKGROUND: New therapeutics are needed for neglected tropical diseases including Human African trypanosomiasis (HAT), a progressive and fatal disease caused by the protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense. There is a need for simple, efficient, cost effective methods t...

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Detalles Bibliográficos
Autores principales: Swinney, Zachary T., Haubrich, Brad A., Xia, Shuangluo, Ramesha, Chakk, Gomez, Stephen R., Guyett, Paul, Mensa-Wilmot, Kojo, Swinney, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778863/
https://www.ncbi.nlm.nih.gov/pubmed/26942720
http://dx.doi.org/10.1371/journal.pntd.0004506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778863/
https://www.ncbi.nlm.nih.gov/pubmed/26942720
http://dx.doi.org/10.1371/journal.pntd.0004506

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