Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph

The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine...

Descripción completa

Detalles Bibliográficos
Autores principales: Monroe, Dougald M., Jenny, Richard J., Van Cott, Kevin E., Buhay, Shelly, Saward, Laura L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779506/
https://www.ncbi.nlm.nih.gov/pubmed/26997955
http://dx.doi.org/10.1155/2016/7678901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779506/
https://www.ncbi.nlm.nih.gov/pubmed/26997955
http://dx.doi.org/10.1155/2016/7678901

Ejemplares similares