Rapid Eye Movement Sleep Deprivation Induces Neuronal Apoptosis by Noradrenaline Acting on Alpha1 Adrenoceptor and by Triggering Mitochondrial Intrinsic Pathway

Many neurodegenerative disorders are associated with rapid eye movement sleep (REMS) loss; however, the mechanism was unknown. As REMS loss elevates noradrenaline (NA) level in the brain as well as induces neuronal apoptosis and degeneration, in this study, we have delineated the intracellular molec...

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Detalles Bibliográficos
Autores principales: Somarajan, Bindu I., Khanday, Mudasir A., Mallick, Birendra N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779900/
https://www.ncbi.nlm.nih.gov/pubmed/27014180
http://dx.doi.org/10.3389/fneur.2016.00025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779900/
https://www.ncbi.nlm.nih.gov/pubmed/27014180
http://dx.doi.org/10.3389/fneur.2016.00025

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