Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation

Post-learning hippocampal sharp wave-ripples (SWRs) generated during slow wave sleep are thought to play a crucial role in memory formation. While in Alzheimer’s disease, abnormal hippocampal oscillations have been reported, the functional contribution of SWRs to the typically observed spatial memor...

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Detalles Bibliográficos
Autores principales: Nicole, Olivier, Hadzibegovic, Senka, Gajda, Judyta, Bontempi, Bruno, Bem, Tiaza, Meyrand, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779992/
https://www.ncbi.nlm.nih.gov/pubmed/26947247
http://dx.doi.org/10.1038/srep22728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779992/
https://www.ncbi.nlm.nih.gov/pubmed/26947247
http://dx.doi.org/10.1038/srep22728

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