Ion Fluxes through K(Ca)2 (SK) and Ca(v)1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A(1) Receptor-Mediated Actions in Spontaneously Beating Rat Atria

Impulse generation in supraventricular tissue is inhibited by adenosine and acetylcholine via the activation of A(1) and M(2) receptors coupled to inwardly rectifying GIRK/K(IR)3.1/3.4 channels, respectively. Unlike M(2) receptors, bradycardia produced by A(1) receptors activation predominates over...

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Detalles Bibliográficos
Autores principales: Bragança, Bruno, Oliveira-Monteiro, Nádia, Ferreirinha, Fátima, Lima, Pedro A., Faria, Miguel, Fontes-Sousa, Ana P., Correia-de-Sá, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780064/
https://www.ncbi.nlm.nih.gov/pubmed/27014060
http://dx.doi.org/10.3389/fphar.2016.00045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780064/
https://www.ncbi.nlm.nih.gov/pubmed/27014060
http://dx.doi.org/10.3389/fphar.2016.00045

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