Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through KRAS activating mutations(1-3). A single endogenous mutant Kras allele is sufficient to promote lung tumour formation in mice but malignant progression requires additional genetic alteratio...

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Detalles Bibliográficos
Autores principales: Kerr, Emma, Gaude, Edoardo, Turrell, Frances, Frezza, Christian, Martins, Carla P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780242/
https://www.ncbi.nlm.nih.gov/pubmed/26909577
http://dx.doi.org/10.1038/nature16967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780242/
https://www.ncbi.nlm.nih.gov/pubmed/26909577
http://dx.doi.org/10.1038/nature16967

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