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Mechanical insights into ribosomal progression overcoming RNA G-quadruplex from periodical translation suppression in cells

G-quadruplexes formed on DNA and RNA can be roadblocks to movement of polymerases and ribosome on template nucleotides. Although folding and unfolding processes of the G-quadruplexes are deliberately studied in vitro, how the mechanical and physical properties of the G-quadruplexes affect intracellu...

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Detalles Bibliográficos
Autores principales: Endoh, Tamaki, Sugimoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780275/
https://www.ncbi.nlm.nih.gov/pubmed/26948955
http://dx.doi.org/10.1038/srep22719