Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Heme is cytotoxic to the plasmodium parasite, which converts it to an insoluble crystalline form called hemozoin (malaria pigment) in erythrocytes during replication. The increased serum levels of free heme cause tissue damage, activation of microvascular endothelial and glial cells, focal inflammat...

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Detalles Bibliográficos
Autores principales: Liu, Mingli, Dickinson-Copeland, Carmen, Hassana, Salifu, Stiles, Jonathan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780719/
https://www.ncbi.nlm.nih.gov/pubmed/27042002
http://dx.doi.org/10.2147/DDDT.S96863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780719/
https://www.ncbi.nlm.nih.gov/pubmed/27042002
http://dx.doi.org/10.2147/DDDT.S96863

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