Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis

We examined the solubility of simvastatin in water in 0.01 mol·dm(−3), 0.02 mol·dm(−3), 0.04 mol·dm(−3), 0.09 mol·dm(−3), 0.18 mol·dm(−3), 0.36 mol·dm(−3), and 0.73 mol·dm(−3) arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies ill...

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Detalles Bibliográficos
Autores principales: Meor Mohd Affandi, MMR, Tripathy, Minaketan, Shah, Syed Adnan Ali, Majeed, ABA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780722/
https://www.ncbi.nlm.nih.gov/pubmed/27041998
http://dx.doi.org/10.2147/DDDT.S94701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780722/
https://www.ncbi.nlm.nih.gov/pubmed/27041998
http://dx.doi.org/10.2147/DDDT.S94701

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