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Solubility enhancement of simvastatin by arginine: thermodynamics, solute–solvent interactions, and spectral analysis
We examined the solubility of simvastatin in water in 0.01 mol·dm(−3), 0.02 mol·dm(−3), 0.04 mol·dm(−3), 0.09 mol·dm(−3), 0.18 mol·dm(−3), 0.36 mol·dm(−3), and 0.73 mol·dm(−3) arginine (ARG) solutions. The investigated drug is termed the solute, whereas ARG the cosolute. Phase solubility studies ill...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780722/ https://www.ncbi.nlm.nih.gov/pubmed/27041998 http://dx.doi.org/10.2147/DDDT.S94701 |