Cargando…

Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice

Pravastatin is a lipid-lowering agent that attenuates atherosclerosis. However, the multifactorial pathogenesis of atherosclerosis requires other drugs with different anti-atherogenic mechanisms. We chose sarpogrelate as an anti-platelet agent and a novel component of a complex drug with pravastatin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Kyung-Yeon, Oh, Euichaul, Kwak, Mi-Kyoung, Jun, Hyun Sik, Heo, Tae-Hwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780828/ https://www.ncbi.nlm.nih.gov/pubmed/26950217 http://dx.doi.org/10.1371/journal.pone.0150791

Ejemplares similares

Beneficial Effects of Sarpogrelate and Rosuvastatin in High Fat Diet/Streptozotocin-Induced Nephropathy in Mice
por: Kim, Dong-hyun, et al.
Publicado: (2016)

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans
por: Min, Jee Sun, et al.
Publicado: (2016)

Suppression of high lipid diet induced by atherosclerosis sarpogrelate
por: Xu, Yan-Jun, et al.
Publicado: (2012)

Sarpogrelate and rosuvastatin synergistically ameliorate aortic damage induced by hyperlipidemia in apolipoprotein E-deficient mice
por: Liu, Hongyang, et al.
Publicado: (2020)

Sarpogrelate hydrochloride ameliorates diabetic nephropathy associated with inhibition of macrophage activity and inflammatory reaction in db/db mice
por: Lee, Eun Soo, et al.
Publicado: (2017)

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy
por: Kwak, Seo Young, et al.
Publicado: (2021)

T Cells in Atherosclerosis in Ldlr−/− and Apoe−/− Mice
por: Getz, Godfrey S., et al.
Publicado: (2018)

Aspirination of α-Aminoalcohol (Sarpogrelate M1)
por: Park, Sunhwa, et al.
Publicado: (2016)

Pravastatin attenuates atherosclerosis after myocardial infarction by inhibiting inflammatory Ly6C(high) monocytosis in apolipoprotein E knockout mice
por: Chen, Yufei, et al.
Publicado: (2020)

HVC1 ameliorates hyperlipidemia and inflammation in LDLR(−/−) mice
por: Cheon, Se-Yun, et al.
Publicado: (2017)

PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice
por: Lee, Samuel K., et al.
Publicado: (2023)

The Role of ERK1/2 Activation in Sarpogrelate-Mediated Neuroprotection
por: Ku, Cristy A., et al.
Publicado: (2018)

PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis
por: Arida, Aikaterini, et al.
Publicado: (2021)

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr(−/−) Mice
por: Peng, Xueying, et al.
Publicado: (2022)

Genetic disruption of multidrug resistance-associated protein 1 improves endothelial function and attenuates atherosclerosis in MRP1(−/−) LDLr(−/−) double knockout mice
por: Jehle, Julian, et al.
Publicado: (2017)

Novel usage of sarpogrelate hydrochloride in patients with allergy-related variant angina
por: Noma, Kensuke, et al.
Publicado: (2012)

Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation
por: Jhun, JooYeon, et al.
Publicado: (2017)

Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(−/−)–LDLR(−/−) Double-Knockout Mice
por: Sanda, Tomohide, et al.
Publicado: (2020)

Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
por: Davis, Bryan T., et al.
Publicado: (2014)

Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
por: Babaev, Vladimir R., et al.
Publicado: (2014)

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr(−/−) mice
por: Rajamoorthi, Ananthi, et al.
Publicado: (2018)

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis
por: Gomes, Diego, et al.
Publicado: (2022)

Tanshinone IIA alleviates atherosclerosis in LDLR(−/−) mice by regulating efferocytosis of macrophages
por: Wang, Jiarou, et al.
Publicado: (2023)

Effect of sarpogrelate treatment on the prognosis after endovascular therapy for critical limb ischemia
por: Takahara, Mitsuyoshi, et al.
Publicado: (2013)

Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice
por: Zhou, Xiaoxu, et al.
Publicado: (2008)

Pravastatin Alleviates Radiation Proctitis by Regulating Thrombomodulin in Irradiated Endothelial Cells
por: Jang, Hyosun, et al.
Publicado: (2020)

Liraglutide Reduces Both Atherosclerosis and Kidney Inflammation in Moderately Uremic LDLr-/- Mice
por: Bisgaard, Line S., et al.
Publicado: (2016)

Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr(−/−) mice
por: Tao, Huan, et al.
Publicado: (2020)

Relationship between Dietary Habits and Control of Lipid Profiles in Patients with Dyslipidemia Using Pravastatin
por: Kang, Seo Young, et al.
Publicado: (2021)

Pravastatin polarizes the phenotype of macrophages toward M2 and elevates serum cholesterol levels in apolipoprotein E knockout mice
por: Zhang, Xiaoling, et al.
Publicado: (2018)

Vitamin D(3) supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR(−/−) and LDLR(+/+) mice
por: Kheder, Ramiar, et al.
Publicado: (2017)

The Prevention of Contrast Induced Nephropathy by Sarpogrelate: a Prospective Randomized Controlled Clinical Trial
por: Ki, You-Jeong, et al.
Publicado: (2019)

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice
por: Riopel, Matthew, et al.
Publicado: (2018)

Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction
por: Lee, Hae-Ri, et al.
Publicado: (2023)

Effects of sarpogrelate, a 5-hydroxytriptamine 2A receptor antagonist on endotoxin shock in rats
por: Nishiyama, T
Publicado: (2005)

Effects of sarpogrelate hydrochloride on peripheral arterial disease: A meta-analysis of randomized controlled trials
por: Lu, Yunxin, et al.
Publicado: (2019)

Protective Role of Sarpogrelate in Combination with Bromocriptine and Cabergoline for Treatment of Diabetes in Alloxan-induced Diabetic Rats
por: Fouad Shalaby, Mohammed, et al.
Publicado: (2021)

Sarpogrelate Based Triple Antiplatelet Therapy Improved Left Ventricular Systolic Function in Acute Myocardial Infarction: Retrospective Study
por: Choi, Jae Hyuk, et al.
Publicado: (2017)

Attenuation of Acetylcholine Activated Potassium Current (I(KACh)) by Simvastatin, Not Pravastatin in Mouse Atrial Cardiomyocyte: Possible Atrial Fibrillation Preventing Effects of Statin
por: Cho, Kyoung-Im, et al.
Publicado: (2014)

Chlamydia pneumoniae Infection Exacerbates Atherosclerosis in ApoB100only/LDLR(−/−) Mouse Strain
por: Lantos, Ildikó, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3u4b3bm4fak18669m2aod5ig2e