The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis

Fingolimod, a structural analog of sphingosine derived from fungal metabolites, is a functional antagonist of the G-protein-coupled sphingosine 1-phosphate (S1P) receptors S1P(1,3,4,5). In the treatment of relapsing forms of multiple sclerosis (RMS), fingolimod acts by reversibly retaining central m...

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Detalles Bibliográficos
Autores principales: Hunter, Samuel F., Bowen, James D., Reder, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781895/
https://www.ncbi.nlm.nih.gov/pubmed/26715391
http://dx.doi.org/10.1007/s40263-015-0297-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781895/
https://www.ncbi.nlm.nih.gov/pubmed/26715391
http://dx.doi.org/10.1007/s40263-015-0297-0

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