Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation

Poly(C)-binding protein 4 (PCBP4), also called MCG10 and a target of p53, plays a role in the cell cycle and is implicated in lung tumor suppression. Here, we found that PCBP4-deficient mice are prone to lung adenocarcinoma, lymphoma, and kidney tumor and that PCBP4-deficient mouse embryo fibroblast...

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Detalles Bibliográficos
Autores principales: Yan, Wensheng, Scoumanne, Ariane, Jung, Yong-Sam, Xu, Enshun, Zhang, Jin, Zhang, Yanhong, Ren, Cong, Sun, Pei, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782047/
https://www.ncbi.nlm.nih.gov/pubmed/26915821
http://dx.doi.org/10.1101/gad.271890.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782047/
https://www.ncbi.nlm.nih.gov/pubmed/26915821
http://dx.doi.org/10.1101/gad.271890.115

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