Single-cell differences in matrix gene expression do not predict matrix deposition

Mesenchymal stem cells (MSCs) display substantial cell-to-cell heterogeneity, complicating their use in regenerative medicine. However, conventional bulk assays mask this variability. Here we show that both chondrocytes and chondrogenically induced MSCs exhibit substantial mRNA expression heterogene...

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Detalles Bibliográficos
Autores principales: Cote, Allison J., McLeod, Claire M., Farrell, Megan J., McClanahan, Patrick D., Dunagin, Margaret C., Raj, Arjun, Mauck, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782061/
https://www.ncbi.nlm.nih.gov/pubmed/26936319
http://dx.doi.org/10.1038/ncomms10865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782061/
https://www.ncbi.nlm.nih.gov/pubmed/26936319
http://dx.doi.org/10.1038/ncomms10865

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