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EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity
Regulated apoptosis of germinal centre (GC) B cells is critical for normal humoral immune responses. ELL-associated factor 2 (EAF2) regulates transcription elongation and has been shown to be an androgen-responsive potential tumour suppressor in prostate by inducing apoptosis. Here we show that EAF2...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782062/ https://www.ncbi.nlm.nih.gov/pubmed/26935903 http://dx.doi.org/10.1038/ncomms10836 |