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EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity

Regulated apoptosis of germinal centre (GC) B cells is critical for normal humoral immune responses. ELL-associated factor 2 (EAF2) regulates transcription elongation and has been shown to be an androgen-responsive potential tumour suppressor in prostate by inducing apoptosis. Here we show that EAF2...

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Detalles Bibliográficos
Autores principales: Li, Yingqian, Takahashi, Yoshimasa, Fujii, Shin-ichiro, Zhou, Yang, Hong, Rongjian, Suzuki, Akari, Tsubata, Takeshi, Hase, Koji, Wang, Ji-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782062/
https://www.ncbi.nlm.nih.gov/pubmed/26935903
http://dx.doi.org/10.1038/ncomms10836