Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

Th9 cells produce interleukin (IL)-9, a cytokine implicated in allergic asthma and autoimmunity. Here we show that Itk, a mediator of T cell receptor signalling required for Th2 immune responses and the development of asthma, is a positive regulator of Th9 differentiation. In a model of allergic lun...

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Detalles Bibliográficos
Autores principales: Gomez-Rodriguez, Julio, Meylan, Françoise, Handon, Robin, Hayes, Erika T., Anderson, Stacie M., Kirby, Martha R., Siegel, Richard M., Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782063/
https://www.ncbi.nlm.nih.gov/pubmed/26936133
http://dx.doi.org/10.1038/ncomms10857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782063/
https://www.ncbi.nlm.nih.gov/pubmed/26936133
http://dx.doi.org/10.1038/ncomms10857

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