Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

Fibroblasts derived from the lungs of patients with idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc) produce low levels of prostaglandin (PG) E(2), due to a limited capacity to up-regulate cyclooxygenase-2 (COX-2). This deficiency contributes functionally to the fibroproliferative st...

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Detalles Bibliográficos
Autores principales: Evans, Iona C., Barnes, Josephine L., Garner, Ian M., Pearce, David R., Maher, Toby M., Shiwen, Xu, Renzoni, Elisabetta A., Wells, Athol U., Denton, Christopher P., Laurent, Geoffrey J., Abraham, David J., McAnulty, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782165/
https://www.ncbi.nlm.nih.gov/pubmed/26744410
http://dx.doi.org/10.1042/CS20150697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782165/
https://www.ncbi.nlm.nih.gov/pubmed/26744410
http://dx.doi.org/10.1042/CS20150697

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