ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

BACKGROUND: p53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. Prognosis of many tumours also depends upon the p53 status. Most of the clinically used anticancer compounds activate p53 dependent...

Descripción completa

Detalles Bibliográficos
Autores principales: Thamkachy, Reshma, Kumar, Rohith, Rajasekharan, K. N., Sengupta, Suparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782294/
https://www.ncbi.nlm.nih.gov/pubmed/26956619
http://dx.doi.org/10.1186/s12943-016-0505-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782294/
https://www.ncbi.nlm.nih.gov/pubmed/26956619
http://dx.doi.org/10.1186/s12943-016-0505-7

Ejemplares similares