Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

BACKGROUND: Secretion of proteopathic α-synuclein (α-SNC) species from neurons is a suspected driving force in the propagation of Parkinson’s disease (PD). We have previously implicated exophagy, the exocytosis of autophagosomes, as a dominant mechanism of α-SNC secretion in differentiated PC12 or S...

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Detalles Bibliográficos
Autores principales: Christensen, Dan Ploug, Ejlerskov, Patrick, Rasmussen, Izabela, Vilhardt, Frederik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782388/
https://www.ncbi.nlm.nih.gov/pubmed/26957005
http://dx.doi.org/10.1186/s12974-016-0519-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782388/
https://www.ncbi.nlm.nih.gov/pubmed/26957005
http://dx.doi.org/10.1186/s12974-016-0519-5

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