Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience

Ketamine, a primarily FDA-approved anaesthetic agent is also used as recreational drug. Based on preclinical findings and later the clinical observations it is noted to have rapid antidepressant effect due to its mechanisms related to NMDA antagonism. In spite of established evidence of ketamine bei...

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Autores principales: Gowda, Mahesh Ramanna, Srinivasa, Preethi, Kumbar, Prabha S., Ramalingaiah, Vinay Hosagavi, Muthyalappa, Chandrashekar, Durgoji, Sumit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782448/
https://www.ncbi.nlm.nih.gov/pubmed/27011405
http://dx.doi.org/10.4103/0253-7176.175121
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author Gowda, Mahesh Ramanna
Srinivasa, Preethi
Kumbar, Prabha S.
Ramalingaiah, Vinay Hosagavi
Muthyalappa, Chandrashekar
Durgoji, Sumit
author_facet Gowda, Mahesh Ramanna
Srinivasa, Preethi
Kumbar, Prabha S.
Ramalingaiah, Vinay Hosagavi
Muthyalappa, Chandrashekar
Durgoji, Sumit
author_sort Gowda, Mahesh Ramanna
collection PubMed
description Ketamine, a primarily FDA-approved anaesthetic agent is also used as recreational drug. Based on preclinical findings and later the clinical observations it is noted to have rapid antidepressant effect due to its mechanisms related to NMDA antagonism. In spite of established evidence of ketamine being effective in depression with significant role in treatment resistant cases as well, there was absolute dearth of literature regarding its utility in grief-related disorders. In this context we present a case of 28-year-old graduate male who presented to us in complicated grief following death of his wife due to obstetric complications. With the patient and immediate family members consenting for use of ketamine as off-label use, patient had single IV infusion of ketamine following which he had unique phenomenological experience ultimately resolving his grief in few minutes. Through this case we highlight the enormous therapeutic promise of ketamine in complicated grief.
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spelling pubmed-47824482016-03-23 Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience Gowda, Mahesh Ramanna Srinivasa, Preethi Kumbar, Prabha S. Ramalingaiah, Vinay Hosagavi Muthyalappa, Chandrashekar Durgoji, Sumit Indian J Psychol Med Case Report Ketamine, a primarily FDA-approved anaesthetic agent is also used as recreational drug. Based on preclinical findings and later the clinical observations it is noted to have rapid antidepressant effect due to its mechanisms related to NMDA antagonism. In spite of established evidence of ketamine being effective in depression with significant role in treatment resistant cases as well, there was absolute dearth of literature regarding its utility in grief-related disorders. In this context we present a case of 28-year-old graduate male who presented to us in complicated grief following death of his wife due to obstetric complications. With the patient and immediate family members consenting for use of ketamine as off-label use, patient had single IV infusion of ketamine following which he had unique phenomenological experience ultimately resolving his grief in few minutes. Through this case we highlight the enormous therapeutic promise of ketamine in complicated grief. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4782448/ /pubmed/27011405 http://dx.doi.org/10.4103/0253-7176.175121 Text en Copyright: © 2016 Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Gowda, Mahesh Ramanna
Srinivasa, Preethi
Kumbar, Prabha S.
Ramalingaiah, Vinay Hosagavi
Muthyalappa, Chandrashekar
Durgoji, Sumit
Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title_full Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title_fullStr Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title_full_unstemmed Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title_short Rapid Resolution of Grief with IV Infusion of Ketamine: A Unique Phenomenological Experience
title_sort rapid resolution of grief with iv infusion of ketamine: a unique phenomenological experience
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782448/
https://www.ncbi.nlm.nih.gov/pubmed/27011405
http://dx.doi.org/10.4103/0253-7176.175121
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