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Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination by bringing together the substrate with an E2 ubiq...

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Detalles Bibliográficos
Autores principales: Boomsma, Wouter, Nielsen, Sofie V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus, Ellgaard, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782732/
https://www.ncbi.nlm.nih.gov/pubmed/26966660
http://dx.doi.org/10.7717/peerj.1725