Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor

Carbonic anhydrase IX (CAIX) is a tumor-associated antigen and marker of hypoxia that is overexpressed on > 90% of clear-cell type renal cell carcinoma (RCC) but not on neighboring normal kidney tissue. Here, we report on the construction of two chimeric antigen receptors (CARs) that utilize a ca...

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Detalles Bibliográficos
Autores principales: Lo, Agnes Shuk-Yee, Xu, Chen, Murakami, Akikazu, Marasco, Wayne A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782938/
https://www.ncbi.nlm.nih.gov/pubmed/27119093
http://dx.doi.org/10.1038/mto.2014.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782938/
https://www.ncbi.nlm.nih.gov/pubmed/27119093
http://dx.doi.org/10.1038/mto.2014.3

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