Enhanced efficacy with azacytidine and oncolytic BHV-1 in a tolerized cotton rat model of breast adenocarcinoma

Oncolytic viruses selectively replicate in cancer cells by exploiting biochemical differences between normal and tumor cells. Treatment with epigenetic modifiers such as 5-Azacytidine, a DNA methyltransferase inhibitor, increases the replication and cytotoxicity of oncolytic viruses in vivo and in v...

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Detalles Bibliográficos
Autores principales: Cuddington, Breanne P, Verschoor, Meghan, Ashkar, Ali, Mossman, Karen L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782958/
https://www.ncbi.nlm.nih.gov/pubmed/27119103
http://dx.doi.org/10.1038/mto.2015.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782958/
https://www.ncbi.nlm.nih.gov/pubmed/27119103
http://dx.doi.org/10.1038/mto.2015.4

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