Mutational and Structural Analysis of Conserved Residues in Ribose-5-Phosphate Isomerase B from Leishmania donovani: Role in Substrate Recognition and Conformational Stability

Ribose-5-phosphate isomerase B from Leishmania donovani (LdRpiB) is one of the potential drug targets against visceral leishmaniasis. In the present study, we have targeted several conserved amino acids for mutational analysis (i.e. Cys69, His11, His102, His138, Asp45, Tyr46, Pro47 and Glu149) to ga...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaur, Preet Kamal, Tripathi, Neha, Desale, Jayesh, Neelagiri, Soumya, Yadav, Shailendra, Bharatam, Prasad V., Singh, Sushma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783025/
https://www.ncbi.nlm.nih.gov/pubmed/26953696
http://dx.doi.org/10.1371/journal.pone.0150764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783025/
https://www.ncbi.nlm.nih.gov/pubmed/26953696
http://dx.doi.org/10.1371/journal.pone.0150764

Ejemplares similares